Oxygen is both vital and toxic for life. A mismatch of oxygen supply and demand underlies countless clinical conditions ranging from inborn errors of metabolism (e.g. mitochondrial disease) to the leading causes of death (e.g. stroke, heart attacks and respiratory disease). We strive to unlock the mysteries of how the human body senses and responds to variations in oxygen levels. Using systems-level approaches, we plan to identify metabolic conditions which benefit from turning the “oxygen dial” to low or high oxygen. This will lay the groundwork to understanding the role of oxygen in aging and age-associated conditions. By viewing metabolism through the lens of oxygen, we hope to understand disease pathologies and pave the path for new therapies.
JainLab@UCSF 