Publications

1. A. H. Baik, I. H. Jain. Turning the oxygen dial: balancing the highs and lows. Trends in Cell Biology. (2020) (PDF)

2. I. H. Jain*, S. E. Calvo*, A. L. Markhard…V. K. Mootha. Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism. Cell, 181, 1-12 (2020). [*, **equal contribution] (PDF)

3. I. H. Jain*, L. Zazzeron*, Goldberger, O…W.M. Zapol**, V. K. Mootha**. Leigh syndrome mouse model can be rescued by interventions that normalize brain hyperoxia, but not HIF activation. Cell Metabolism, 30, 1-9 (2019). [*, **equal contribution] (PDF)

*    Preview: Breath: Your Mitochondria Will Do the Rest…If They Are Healthy!

4. M. Ferrari*, I. H. Jain*, Goldberger, O…V. K. Mootha**, W.M. Zapol**. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. PNAS, 114 (21), E4241-E4250 (2017). [*equal contribution] (PDF) (PubMed)

*    News: Low Oxygen Reverses Mitochondrial Disease (HHMI)

5. I. H. Jain, L. Zazzeron, R. Goli…F. Zhang, W. Goessling, W. M. Zapol, V. K. Mootha. Hypoxia as a therapy for mitochondrial disease. Science, 352 (6281), 54-61 (2016). (PDF) (PubMed)

*    News: Oxygen Deprivation Counters Deadly Mitochondrial Disease in Animals
*    Perspective: Mitochondrial Disease Therapy from Thin Air

6. I. H. Jain*, V. Vijayan*, E.K. O’Shea. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. PNAS, 109 (34), 13638-13643 (2012). [*equal contribution] (PDF) (PubMed)

7. V. Vijayan, I. H. Jain, E.K. O’Shea. A high resolution map of a cyanobacterial transcriptome. Genome Biology, 12:R47 (2011). Highly accessed article. (PDF) (PubMed)

8. A. D. Hoptak-Solga, S. Nielsen, I. H. Jain, R. Thummel, D. Hyde, and M. K. Iovine. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology, (2008)

9. I. H. Jain, C. Stroka, J. Yan, W. Huang, M. K. Iovine. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Developmental Dynamics, 236, 2668-2674 (2007)

10. A. Sharma, H. Jain, J. O. Carnali, I. H. Jain. Inhomogeneous evolution of a glass surface via free, rapid expansion. Applied Physics Letters, 83, 2802-2804 (2003)