15. A. H. Baik*, A. G. Haribowo*, X. Chen*, B. B. Queliconi, A. M. Barrios, A. Garg, M. Maishan, A. R. Campos, M. A. Matthay, I. H. Jain. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Molecular Cell. 83, 1-19. [*equal contribution] (2023) (PDF)
14. A. M. Midha*, Y. Zhou*, B. B. Queliconi, A. M. Barrios, C. O. Y. Fong, J. E. Blecha, H. VanBrocklin, Y. Seo, I. H. Jain. Organ-Specific Fuel Rewiring in Acute and Chronic Hypoxia Redistributes Glucose and Fatty Acid Metabolism. Cell Metabolism. 35, 504-516. [*equal contribution] (2023) (PDF)
- Preview: Unanticipated metabolic plasticity in response to chronic hypoxia
- News: How high altitude changes your body’s metabolism
13. W. R. Flanigan, I. H. Jain. The Goldilocks Oxygen Principle: not too little and not too much. Nature Cardiovascular Research. 1, 1101–1103 (2022) (PDF)
12. M. Ravichandran, J. Hu…B. R. Desousa…I. H. Jain…R. M. Perera. Coordinated transcriptional and catabolic programs support iron-dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer. Cancer Discovery. OF1–OF22 (2022).
11. M. Shivaraju, U. K. Chitta, R. M. H. Grange, I. H. Jain…J. Rajagopal. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 371, 52-57 (2021).
10. A. H. Baik, I. H. Jain. Turning the oxygen dial: balancing the highs and lows. Trends in Cell Biology. (2020) (PDF)
9. I. H. Jain*, S. E. Calvo*, A. L. Markhard…V. K. Mootha. Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism. Cell, 181, 1-12 (2020). [*, **equal contribution] (PDF)
8. I. H. Jain*, L. Zazzeron*, Goldberger, O…W.M. Zapol**, V. K. Mootha**. Leigh syndrome mouse model can be rescued by interventions that normalize brain hyperoxia, but not HIF activation. Cell Metabolism, 30, 1-9 (2019). [*, **equal contribution] (PDF)
7. M. Ferrari*, I. H. Jain*, Goldberger, O…V. K. Mootha**, W.M. Zapol**. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. PNAS, 114 (21), E4241-E4250 (2017). [*equal contribution] (PDF) (PubMed)
6. I. H. Jain, L. Zazzeron, R. Goli…F. Zhang, W. Goessling, W. M. Zapol, V. K. Mootha. Hypoxia as a therapy for mitochondrial disease. Science, 352 (6281), 54-61 (2016). (PDF) (PubMed)
- News: Oxygen Deprivation Counters Deadly Mitochondrial Disease in Animals
- Perspective: Mitochondrial Disease Therapy from Thin Air
5. I. H. Jain*, V. Vijayan*, E.K. O’Shea. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. PNAS, 109 (34), 13638-13643 (2012). [*equal contribution] (PDF) (PubMed)
4. V. Vijayan, I. H. Jain, E.K. O’Shea. A high resolution map of a cyanobacterial transcriptome. Genome Biology, 12:R47 (2011). Highly accessed article. (PDF) (PubMed)
3. A. D. Hoptak-Solga, S. Nielsen, I. H. Jain, R. Thummel, D. Hyde, and M. K. Iovine. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology, (2008).
2. I. H. Jain, C. Stroka, J. Yan, W. Huang, M. K. Iovine. Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation. Developmental Dynamics, 236, 2668-2674 (2007)
1. A. Sharma, H. Jain, J. O. Carnali, I. H. Jain. Inhomogeneous evolution of a glass surface via free, rapid expansion. Applied Physics Letters, 83, 2802-2804 (2003).
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