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Isha Jain, PhD (CV)   Principal Investigator (

Isha received her undergraduate degree in Chemical and Physical Biology from Harvard University. There, she worked in the lab of Erin O’Shea on bacterial chromosome segregation. Subsequently, she joined the Harvard-MIT Program in Health Sciences and Technology. During her PhD, she worked in the labs of Vamsi Mootha and Warren Zapol, where she made the discovery that hypoxia could serve as a therapy for mitochondrial disorders. This work has led to a Phase 1 clinical trial. Isha joined UCSF as a Sandler Faculty Fellow in Summer 2018.


    Kirsten Chen, B.S.    BMS PhD Student

Kirsten grew up in China and earned her BS from University of North Carolina, Chapel Hill. There she completed a double major in chemistry and biology. At UNC, she worked in the lab of Dr. Steve Hursting on metabolic reprogramming during cancer progression to metastasis and differential responses to folate deficiency in a murine model of triple-negative breast cancer. As a BMS student, Kirsten hopes to use experimental and computational approaches to study the complexities of biological systems and disease. Outside of work, she enjoys dancing, traveling and exploring good food and coffee.


  Alan Baik, M.D.      Cardiology Fellow

Alan was born in Los Angeles and attended Harvard University, where he majored in biology. He completed medical school and internal medicine residency at UCSF. As a Sarnoff Cardiovascular Research Fellow, he worked in the lab of Bill Kaelin at the Dana-Farber Cancer Institute, studying the mechanisms of remote ischemic preconditioning in a murine model of cardiac ischemia-reperfusion. Alan is currently a cardiology fellow at UCSF, interested in better understanding oxygen metabolism and signaling in myocardial infarction and cardiovascular disease.


Ankur Garg, PhD Postdoctoral Fellow

Ankur attended IIT Delhi for her undergraduate studies in Biochemical Engineering and Biotechnology. She received her PhD in Molecular Biology and Genetics, in the lab of Xin Zhang at Columbia University studying the role of Fgf signaling in tear gland development. During a post-doc at UCSD, she worked in the lab of Xin Sun where she studied pulmonary neuroendocrine cells. She is now interested in studying the signaling mechanisms underlying hypoxia as a therapeutic intervention for neurodegenerative and metabolic disorders.


    Alec Barrios, B.S.    Research Specialist

Alec was born in Whittier and earned his BS from the University of California, Santa Barbara, where he majored in pharmacology. At UCSB, he worked in the lab of Dr. Joel Rothman on the mechanism of cellular reprogramming in pharyngeal tissue and the effects of reprogramming on mitochondrial function. As a research associate, Alec is studying the role of acute vs. chronic hypoxia on whole-body adaptations, with the goal of developing novel therapies for states of ischemia.


    Chirasree Mandal     Undergrad Student

Chirasree grew up in Evanston, Illinois and is currently an undergrad at UC Berkeley studying Computer Science and Data Science. She previously worked in the Pinkett Lab at Northwestern University, where she developed computational protocols and algorithms for studying ABC transporters. At the Jain Lab, Chirasree is interested in developing software, web applications, and data pipelines for vitamin & oxygen metabolism. In her spare time, she likes reading sci-fi, drinking cold-brew coffee, and taking polaroids.


         Brandon Desousa         BMS Rotation Student

Brandon was born and raised in South Florida. He received a B.S. in Biochemistry and Neuroscience at the University of Miami. There, he worked on how neural stem cells can contribute to recovery after a brain injury. He then joined Dr. Ajit Divakaruni’s mitochondrial bioenergetics lab at UCLA and studied the bioenergetics of glioblastoma and macrophage inflammatory activation. Outside of the lab, Brandon enjoys discovering new films at independent cinemas, and working towards crafting the perfect cup of coffee.